The softball program at LaGrange College competed for the first time as a varsity sport in 1981.  It was slow-pitch, and enjoyed some fantastic seasons, including its national championship run in 1994.  The program was an NAIA affiliate and had the vision of becoming a NCAA Division III member, which started the first talk of changing the sport to fastpitch, which it currently is today.

The current head coach, Jennifer (DeMooney) Claybrook has been with the program since the inception of the sport in the fall of 1996. The first season was in the spring of 1997 with only Dana Camp, Laura Bullard, Paula Davis, and Beth Winter with existing fastpitch experience.  The Panthers, led by head coach Larry Thompson, posted an amazing 47-21 record and a berth into the NAIA post-season in the first season of the sport! It also earned its first-ever fast pitch GACC Conference Championship and posting a top 25 NAIA national ranking.

In the inaugural 1997 Season the young lady panthers made their presence felt putting up a 47-21 record, featuring a 32 game winning pitcher in Paula Davis and a true slugger in  Miki Deal (5 home runs overall; two in one game).

The following year, coach Kelly Britsky, a former LC player and a member of the 1994 National Championship team as an assistant coach, was left with six players as the school started its transition into NCAA Division III. The program endured some hardships playing against scholarship schools, but performed above expectations.

The 1998 season, brought the Panthers into a transitional period, a transition that took its form in the worst overall record to date (17-31). The bright side of this year was the emergence of Jennifer DeMooney, who left the program as the school's leader in various all-time offensive records.

1999 was a year of reemergence for the Panthers, with the lead of Jennifer Brown and Jennifer DeMooney and an excellent surrounding cast, the Panthers peaked above .500 once again with a 27-26 record, topping all expectations of all their critics.  It would be the final season for Kelly Britsky as head softball coach, as Shelly Whitaker would come in as the third head coach in four years for the young program.

The 2000 season was marked by a decline in wins, but a steady move in the right direction modeling the student-athlete.  The Panthers finished third in the nation with a overall GPA of 3.42. 

They did good on the field as well, ranking themselves second in the conference in batting average.  Two players; DeMooney and Kelly Wren, were both named First-Team All-GACC.  The awards didn't stop there as DeMooney earned First-Team All-Region while Wren was named Freshman of the Year in the conference. 

In addition to their awards on the field, the Panthers had 10 players who were named Academic All-GACC including four who were named NAIA/NFCA Academic All-America (DeMooney, Samantha Henderson, Crystal Kersey and Beth Winter).

In 2001, the Panthers captured its first-ever Great South Athletic Conference Championship.  Four players were named All-GSAC (Kersey, Sabrina Pace, Shannon Phillips and Liana Thorton) while six others were named to the GSAC All-Freshman team. 

Shannon Phillips emerged as the top freshman in the GSAC, in addition to earning All-Freshman and All-GSAC honors, she was also voted NAIA second-team All-Region.  Phillips would emerge into one of the program's best players with her instant offense at the plate and in the field.  She would be named Third-Team All-America third baseman the following year as a sophomore.

The team did well in the classroom as well, ranking themselves 15th in the nation once again in team overall GPA.

The 2003 season featured five USCAA All-Americans (along with three honorable mentions and two academic All-Americans), 10 GSAC All-Conference award winners, and nine GSAC All-Freshmen award winners.  It was also a year of transistion, as Jennifer DeMooney Claybrook was named head coach.  She has been with the program as both a player and as an assistant coach prior to becoming head coach of the Panthers and would bring the program back to the prominence it enjoyed in the 1990's. 

Led by the bat of Jessica DeMooney (six home runs) and the arm of Kelly Wren (1.45 ERA; 11 wins in 20 starts) this may have been the most productive team in the short history of the program with an impressive 25-17 record, ending with Claybrook being named GSAC Coach of the Year in her first season.

In 2004 the fast pitch program took a step back finishing three games under .500 (21-24 overall) after finishing eight games above in the previous season. Though still a talented team production went down but a few players stood out; with USCAA All-American and GSAC Player of the Year Jessica DeMooney and fellow USCAA All-American Kim Woodard in particular.

In 2005, on the lead of Kellee Scandrett (.398 Batting average and three home runs), Jessica DeMooney (.398 Batting average along with accounting for 35 runs), and Pitcher Farrah McCullough (11 wins; 1.66 ERA) the Panthers- boasting both four USCAA All-Americans and GSAC All-Conference awardees- rolled into the GSAC tournament finishing as runner-up with a 26-17 record, a five-win improvement from last season.

The 2006 Panther squad had it's best season since coming to NCAA divsion III.  It's 32 wins were the most since that transition along with the program's best-ever .744 winning percentage, eclipsing the old record set in 1997. 

Seven players were named All-GSAC, including Jessica DeMooney, who was named GSAC Player of the Year along with Amanda Daniel, who was named Freshman of the Year in the GSAC.  DeMooney and Kim Woodard were voted to the NFCA All-Region Team.

The Panthers consistently play a very competitive softball schedule in and out of their conference.  They are allowed to play 40 games in the spring and one competition date in the fall.  LaGrange College is a member of the Great South Athletic Conference (GSAC). The GSAC is made up of seven member schools in which all schools compete for the softball conference title.  The seven teams are able to compete for the conference title and the automatic bid to the NCAA Tournament.